Leprosy in elderly people and the profile of a retrospective cohort in an endemic region of the Brazilian Amazon.

BACKGROUND: Leprosy has a global presence; more than 180 thousand new cases were registered in 2013, 15% of which were found in the Americas. The elderly are a very susceptible demographic in terms of developing illnesses, mainly because of characteristics natural to the senescence of the human organism. This study's goals were to analyze leprosy in an elderly population from a hyperendemic region of the Brazilian Amazon in a historical series from 2004 to 2013 and to determine the clinical and epidemiological profile of a series of leprosy cases of elderly people in the period spanning from 2009 to 2013. METHODS: To achieve these goals, an observational, longitudinal, retrospective and descriptive study was put together to analyze leprosy in elderly people from data acquired from the Notification Aggravations Information System. Furthermore, a profile of the disease from a retrospective cohort based on data collected from medical records was developed. RESULTS: The number of new cases and the leprosy detection rate decreased across the observed period but remained stable among the elderly. The trend for the next ten years indicates decreases in the number of cases and in the detection rate in the general population and an increase in only the elderly. The overall profile was characterized by a predominance of males (64.32%), the multibacillary clinical form (87.57%), Type 1 reaction episodes (37.50%) and some physical incapacity at diagnosis (49.19%). The risk of reaction was greater in the first six months of multidrug therapy, and the positive result from the skin smear was associated with the greater chance of reactional condition development. CONCLUSIONS: The resulting data demonstrate that leprosy amongst the elderly deserves attention because of the increased susceptibility to disability in this age group, with their higher risk of reaction and their greater level of co-morbidity.

Association between sarcopenia and diabetes in community dwelling elderly in the Amazon region - Viver Mais Project.

BACKGROUND: Studies indicate the intrinsic relationship between sarcopenia and diabetes mellitus (DM) pathophysiological mechanisms. Changes in insulin and muscular metabolism are features of diabetic patients and can interact as sarcopenic accelerators. Conversely, sarcopenic patients feature lower glucose tolerance and higher serum insulin levels, predisposing them to DM. OBJECTIVE: To study the association between sarcopenia and DM in a community-dwelling elderly population of the Amazon region. METHODS: Cross-sectional study, performed in Belém, Brazil, with 1078 patients aged above 60 years old from the Viver Mais Project (VMP). The definition of sarcopenia was based in the European Working Group on Sarcopenia in Older People (EWGSOP). Calf circumference >31 cm was considered normal, muscle strength was discriminated by BMI and measured with the hand grip test, and gait speed <0.8 m/s configured low performance. DM was diagnosed when reported by the patient or medical form, use of hypoglycemic medications/insulin and in the presence of fasting glucose >126 mg/dl or glycated hemoglobin (HbA1c) >6.5% on two occasions. Other medical and socio-demographic data were extracted from medical forms. RESULTS: The frequency of sarcopenia was 9.4%, while DM was present in 36.87% of the patients, and had an increased occurrence in the sarcopenic group. Female sex, advanced age, DM, coronary insufficiency, osteoporosis, body mass index, waist circumference, triglycerides and functionality were associated with sarcopenia. In multivariate analysis, sarcopenia remained strongly associated with DM (OR: 3.208, 95%CI: 1.784-5.769). CONCLUSION: This study describes strong and independent association between sarcopenia and DM. To further clarify these findings, broader prospective cohorts are necessary.

Chronic pain in long-lived elderly: prevalence, characteristics, measurements and correlation with serum vitamin D level / Dor crônica em idosos longevos: prevalência, características, mensurações e correlação com nível sérico de vitamina D

ABSTRACTBACKGROUND AND OBJECTIVES:Chronic pain considerably worsens quality of life of the elderly, giving relevance to studies addressing it in such individuals, especially those long-lived. Recently, vitamin D deficiency, very prevalent among the elderly, has been correlated to chronic pain. This study aimed at estimating the prevalence of chronic pain among community long-lived elderly with functional independence, at evaluating its characteristics and at correlating this pain to serum vitamin D levels.METHODS:Cross-sectional study of the “Long-Lived Project”, with elderly aged 80 years or above, of both genders, with functional independence. Socio-demographic data were collected, referred chronic pains were measured and serum vitamin D levels were obtained.RESULTS:We have evaluated 330 participants of the “Long-Lived Project” and pain prevalence was 20.9%, especially nociceptive, continuous, moderate to severe and lumbar pain. Among pain intensity measurement tools, faces and verbal numeric scales were preferred. There has been high prevalence of vitamin D deficiency among long-lived elderly with chronic pain (87%); deficiency and insufficiency levels were 49 and 38%, respectively, however such levels were not significantly correlated to chronic pain.CONCLUSION:There has been high prevalence of chronic pain among the elderly. Moderate to severe and low back pain were the most frequent. There has been high prevalence of vitamin D deficiency among studied long-lived elderly; however there has been no significant correlation between low serum vitamin D levels and chronic pain.

RESUMOJUSTIFICATIVA E OBJETIVOS:A dor crônica diminui consideravelmente a qualidade de vida dos idosos, dando relevância aos estudos que a abordam nesses indivíduos, sobretudo nos longevos. Recentemente, a hipovitaminose D, muito prevalente entre idosos, tem sido relacionada à dor crônica. O objetivo deste estudo foi estimar a prevalência de dor crônica entre os longevos da comunidade com independência funcional, avaliar suas características e correlacionar essa dor com os níveis séricos de vitamina D.MÉTODOS:Estudo transversal do “Projeto Longevos”, com idosos de 80 anos ou mais, de ambos os gêneros, com independência funcional. Foram apurados os dados sócio-demográficos, avaliadas e mensuradas as dores crônicas apresentadas e obtidos os níveis séricos da vitamina D.RESULTADOS:Foram avaliados 330 participantes do “Projeto Longevos”, e encontrada prevalência de 20,9% de dor crônica, sendo essa principalmente do tipo nociceptiva, contínua, de intensidade moderada a intensa, de localização lombar. Dentre os instrumentos de mensuração da intensidade dolorosa, os preferidos foram as escalas de faces e numérica verbal. Observou-se alta prevalência de hipovitaminose D nos longevos com dor crônica (87%); níveis de deficiência e insuficiência em 49 e 38%, respectivamente, porém tais níveis não se correlacionaram significativamente com a presença de dor crônica.CONCLUSÃO:A prevalência de dor crônica entre os longevos foi alta. Intensidade moderada e intensa e localização lombar foram as mais frequentes. Houve alta prevalência de hipovitaminose D entre os longevos estudados, porém não se observou correlação significativa entre baixos níveis séricos de vitamina D e dor crônica.

Vitamina D e dor crônica em idosos / Vitamin D and chronic pain in the elderly

BACKGROUND AND OBJECTIVES: Chronic pain is a frequent complaint during medical visits, especially among the elderly. In the attempt to find more effective therapies with less adverse effects in this population, especially considering elderly people with neuropathic and musculoskeletal pain, there are studies relating vitamin D to pain, which could propose it as an analgesic alternative. This study aimed at reviewing in the literature the role of vitamin D in chronic musculoskeletal pain in the elderly. CONTENTS: Pubmed, Medline, LILACS, Cochrane Library and Scielo databases were queried for the last ten years, looking for studies in Portuguese and English. Initial search keywords were "vitamin D" and "chronic pain", resulting in 220 articles, of which only those addressing musculoskeletal pain in the elderly were selected. From those, only ten met established criteria and were analyzed, resulting in: one systematic review, five transversal analytical studies, two case-series retrospective studies, one prospective observational study and one randomized and controlled clinical trial. Five studies have shown significant relationship between vitamin D deficit and chronic musculoskeletal pain; three studies have shown pain improvement after vitamin D supplementation and two have not observed pain improvement with such supplementation. CONCLUSION: Studies relating vitamin D to chronic pain in the elderly are still scarce and highly heterogeneous. The evaluation of vitamin D deficit should be more frequent during geriatric consultations, because this has been correlated to some painful syndromes and its correction could bring therapeutic benefits in some cases.

JUSTIFICATIVA E OBJETIVOS: A dor crônica é queixa muito frequente nas consultas, principalmente entre os idosos. Na tentativa de buscar terapêuticas mais eficazes e com menos efeitos adversos, nessa população, especialmente considerando idosos com dor neuropática e musculoesquelética, tem-se observado estudos que vêm relacionando a vitamina D a quadros dolorosos, o que poderia propô-la como uma alternativa analgésica. O objetivo deste estudo foi rever, na literatura, o papel da vitamina D na dor crônica neuromusculoesquelética em idosos. CONTEÚDO: Realizada a revisão bibliográfica na base de dados do Pubmed, Medline, LILACS, Biblioteca Cochrane e Scielo, contemplando os últimos 10 anos, títulos em português e inglês. Os descritores usados na busca inicial foram "vitamina D" e "dor crônica", resultando 220 artigos, dos quais apenas os que se tratavam de dor neuromusculoesquelética em idosos foram utilizados. Destes, somente 10 preenchiam os critérios estabelecidos e foram analisados, resultando: um estudo de revisão sistemática, cinco estudos analíticos transversais, dois estudos retrospectivos do tipo série de casos, um estudo observacional prospectivo e um trial clínico randomizado e controlado. Observou-se em cinco estudos uma relação significativa entre a hipovitaminose D e dor crônica musculoesquelética, em três estudos uma melhora da dor após suplementação com vitamina D, e, em outros dois, não haver melhora da dor com esta suplementação. CONCLUSÃO: Os estudos relacionando a vitamina D e a dor crônica em idosos ainda são escassos e bastante heterogêneos. A avaliação do déficit de vitamina D deveria estar mais presente nas consultas geriátricas, pois este tem sido correlacionado com certas síndromes dolorosas e sua adequação poderia trazer beneficio terapêutico em alguns casos.

Hipertensão arterial, diabetes mellitus e síndrome metabólica: do conceito à terapêutica / Hypertension, diabetes mellitus and metabolic syndrome: from concept to therapy

Apesar dos avanços ocorridos na prevenção e tratamento da Hipertensão Arterial Sistêmica (HAS), esta continua sendo a mais frequente das doenças crônicas não transmissíveis e o principal fator de risco para doenças cardiovasculares e mortalidade. É um importante problema de saúde pública, estando frequentemente associada ao Diabetes Mellitus (DM) e à Síndrome Metabólica (SM), condições também altamente prevalentes que compartilham com a HAS algumas características: elevado risco cardiovascular; aumento progressivo de prevalência com a idade; relação direta com hábitos de vida inadequados; além de um número cada vez maior de indivíduos afetados. Quando presentes no mesmo indivíduo, estas enfermidades aumentam ainda mais o risco de morbidade e mortalidade cardiovascular (CV). São essenciais medidas preventivas, reconhecimento precoce destas enfermidades e abordagem terapêutica adequada. Esse artigo revisa os conceitos e os principais aspectos da Fisiopatologia, do risco CV e da abordagem terapêutica da HAS, do DM e da SM, com base em estudos clínicos e nas principais diretrizes dessas áreas.

Despite recent discoveries in prevention and treatment of hypertension, it remains the most frequent chronic disease and the main risk factor for cardiovascular morbidity and mortality. It constitutes an important public health problem and is often associated with diabetes mellitus and metabolic syndrome. These conditions share important features with hypertension: progressive prevalence with age, direct association with inadequate life habits, and an increasing number of affected persons in population. When coexisting in the same person, these disorders greatly increase the risk of cardiovascular morbidity and mortality. Preventive measures, early recognition and adequate therapeutic approaches are very important. This article reviews the concepts and the main aspects of the pathophysiology of cardiovascular risk and therapeutic management of hypertension, diabetes and metabolic syndrome from clinical studies and the main guidelines in these areas.

Doenças articulares no idoso / Osteoarticular disease in the elderly

O envelhecimento populacional é responsável pelo aumento da prevalência de doenças osteoarticulares associadas à dor, deformidades articulares e incapacidade funcional. As principais doenças osteoarticulares no idoso são a osteoartrite, artrite reumatoide e gota e essas podem causar dor e, consequentemente, impacto negativo na vida dos idosos. Portanto, o reconhecimento precoce e o tratamento adequado dessas enfermidades são essenciais para a prevenção de deformidades e manutenção da funcionalidade e qualidade de vida destes indivíduos.